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KMID : 1234420100380010013
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 1 p.13 ~ p.18
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Pathogenomic Signaling Networks and Antifungal Drug Development for Human Fungal Pathogen Cryptococcus neoformans
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Ko Young-Joon
Kwon Yoo-Won
Na Han-Na
Bahn Yong-Sun
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Abstract
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Past decade systemic mycoses caused by opportunistic human fungal pathogens, including Candida, Aspergillus, and Cryptococcus, have been a growing problem for both immunocompromised and immunocompetent individuals. Particularly, Cryptococcus neoformans has recently emerged as a major fungal pathogen, which can cause fungal pneumonia and meningitis that are lethal if not timely medicated. However, treatment for cryptococcosis has been difficult due to a lack of proper anti-cryptococcal drugs with fungicidal activity and less toxicity. In this review we introduced novel therapeutic methods for treating cryptococcosis by exploring pathogenomic signaling networks of C. neoformans with genome-wide transcriptome approaches as well as diverse molecular/genetic tools.
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KEYWORD
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Antifungal drugs, cAMP-pathway, Cryptococcus neoformans, fungal pathogen, HOG-pathway, pathogenomic signaling network
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